Experiment 387921
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | ALBRECHT,M: HUBNER,WD: PODZWEIT,H: SCHMIDT,U:. (1994). ST JOHN'S WORT EXTRACT IN THE TREATMENT OF DEPRESSION. OBSERVATIONS ON THE USE OF JARSIN CAPSULES.. 1994() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE TREATMENT OF MILD TO MODERATE DEPRESSION 1060 PATIENTS WITH HIGH DOSE OF ST JOHN'S WORT EXTRACT, OVER A PEROID OF 4 WEEKS WAS MONITERED BY 270 PHYSICIANS. EVALUATION OF TOLERANCE AND EFFICACY WAS CARRIED OUT BY MEANS OF OBJECTIVE AND SUBJECTIVE ASSESSMENT SCALES SUCH AS THE HAMILTON DEPRESSION SCALE (HAMD) AND THE SELF-EVALUATION SCALE (AFTER ZERSSEN). SYMPTOMS WERE SCORED IN TERMS OF FREQUENCY AND SEVERITY. THERE WAS A MARKED CLINICAL REDUCTION IN SYMPTOMS AFTER 4 WEEKS' TREATMENT. THE PATHOLOGICAL HAMD RAW SUMMED SCORES (MEAN VALUE 18.4) REACHED 5.4 POINTS. WHILST THE ZERSSEN SCALE (21.1) REACHED NORMAL LIMITS AT 7.3 POINTS. SYMPTOMS OF DEPRESSION HAD DISAPPEARED IN OVER 74% OF PATIENTS. TYPICAL MOOD DISORDERS REDUCED BY 65-78% UNDER TREATMENT. THE TOTAL SELF-ASSESSMENT SCORES FELL FROM 9.5 TO 2.8 POINTS (A FALL OF 71% ON AVERAGE), THUS SIGNIFYING MARKED IMPROVEMENT. TOLERANCE WAS DEEMED AS VERY GOOD BY MORE THAN 90% OF PATIENTS: ONLY 2% COMPLAINED OF UNWANTED DRUG SIDE EFFECT. |
| Dose amount | 900.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |