Experiment 387941
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | SCHRADER,E: MEIER,B: BRATTSTROM,A:. (1998). HYPERICUM TREATMENT OF MILD-MODERATE DEPRESSION IN A PLACEBO-CONTROLLED STUDY. A PROSPECTIVE, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, MULTICENTRE STUDY.. 13() |
| Amount utilized | |
| Compound isolated | |
| Disease | A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED STUDY ASSESSED THE SAFETY AND EFFICACY OF AN ETHANOL EXTRACT OF THE HERB FOR THE TREATMENT OF 151 PATIENTS WITH MILD TO MODERATE DEPRESSION (ICD-10; F 32.1 MODERATE). PATIENTS RECEIVED 250 MG TABLETS OF THE EXTRACT TWICE DAILY (CORRESPONDING TO 1 MG HYPERICIN) OR PLACEBO FOR 6 WEEKS. THE PRIMARY EFFICACY VARIABLE WAS HAMILTON DEPRESSION SCALE (HAMD), AND SECONDARY VARIABLES WERE THE RISK-BENEFIT CLINICAL GLOBAL IMPRESSIONS SCALES I-III AND A VALIDATED PATIENT SELF-ASSESSMENT ON A VISUAL ANALOGUE SCALE (SCHRADER ET AL 1998). AFTER 6 WEEKS OF THERAPY, DECREASES IN THE HAMD SCORE, 56% OF PATIENTS TREATED WITH THE EXTRACT WERE CLASSIFIED AS RESPONDERS AS COMPARED WITH 15% OF PATIENTS TAKING PLACEBO. |
| Dose amount | 500.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |