Experiment 39156

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismCorydalis ambigua (PAPAVERACEAE)
CitationHSU,B: KIN,KC:. (1962). PHARMACOLOGICAL STUDY OF TETRAHYDROPALMATINE AND ITS ANALOGS. A NEW TYPE OF CENTRAL NERVOUS SYSTEM DEPRESSANT.. 139()
Amount utilized
Compound isolated
DiseaseE RESULTS OBTAINED ON SEVERAL HUNDREDS OF PATIENTS SHOWED THAT THP WAS RATHER FAVORABLE FOR THOSE PATIENTS WITH DULL VISCERAL PAIN. SIDE REACTIONS SUCH AS VOMITING, CONSTIPATION AND RESPIRATORY DEPRESSION HAVE NOT BEEN OBSERVED. NEITHER DID ADDICTION OCCUR AFTER REPEATED ADMINISTRATION. THP WAS ALSO USED AS AN INTER­MEDIATE OR SHORT ACTING HYPNOTIC IN PATIENTS WITH INSOMNIA. IT DID NOT GIVE AFTER-EFFECTS SUCH AS FAINTNESS, HEADACHE, ETC. IN SOME CASES THP COULD ALLEVIATE THE SYMPTOMS OF NERVOUS TENSION. BASED ON OUR EXPERI­MENTAL RESULTS AND CLINICAL DATA, IT MAY BE CONCLUDED THAT THE ANALGESIC POTENCY OF THP IS WEAKER THAN THAT OF MORPHINE, BUT ITS HYPNOTIC ACTION IS STRONGER. THE TRANQUILLIZING EFFECT OF THP IS WEAKER THAN THAT OF CHLORPROMAZINE. IT MAY THUS BE SUGGESTED THAT THP BELONGS TO A NEW TYPE OF CENTRAL DEPRESSANTS WHICH IS SITUATED BETWEEN ANALGESICS AN TRANQUILIZERS.
Number4
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE