| Disease | ORAL ADMINISTRATION OF 250, 750, AND 1,500 MG OF H AND 526, 1,578, AND 3,156 MG OF PH RESULTED IN LEAK LEVELS IN PLASMA (CMAX) OF 1.3, 7.2, AND 16.6 MG/LITER FOR H AND 3.4, 12.1, AND 29.7 MG/LITER FOR PH, RESPECTIVELY. THE CMAX AND THE AREA
UNDER THE CURVE VALUES FOR THE LOWEST DOSE WERE DISPROPORTIONALLY LOWER THAN THOSE FOR THE HIGHER DOSES. A LAG TIME OF 1.9 H FOR H WAS REMARKABLY LONGER THAN THE 0.4-H LAG TIME FOR PH. MEDIAN HALF-LIVES FOR ABSORPTION, DISTRIBUTION, AND
ELIMINATION WERE 0.6, 6.0, AND 43.1 H AFTER 750 MG OF H AND 1.3, 1.4, AND 24.8 H AFTER 1,578 MG OF PH, RESPECTIVELY. FOURTEEN-DAY TREATMENT WITH 250 MG OF H AND 526 MG OF PH THREE TIMES A DAY RESULTED IN MEDIAN STEADY-STATE TROUGH LEVELS OF 7.9
MG/LITER FOR H AND 4.8 MG/LITER FOR PH AFTER 7 AND 4 DAYS, RESPECTIVELY; THE CORRESPONDING CMAX LEVELS WERE 8.8 AND 8.5 MG/LITER, RESPECTIVELY. |