Experiment 393395
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | GURGUIS,GNM: VITTON,BJ: UHDE,TW:. (1997). BEHAVIORAL, SYMPATHETIC AND ADRENOCORTICAL RESPONSES TO YOHIMBINE IN PANIC DISORDER PATIENTS AND NORMAL CONTROLS.. 71(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | A CLINICAL TRIAL EXAMINED THE BEHAVIORAL, PERIPHERAL SYMPATHETIC AND ADRENOCORTICAL RESPONSES TO ORAL YOHIMBINE IN 7 HEALTHY CONTROLS AND 11 PATIENTS DIAGNOSED WITH AGORAPHOBIA WITH PANIC ATTACKS (PD). PATIENTS DID NOT DIFFER IN BASELINE CARDIOVASCULAR OR NEUROENDOCRINE MEASURES FROM CONTROLS DISPITE SIGNIFICANTLY HIGHER BASELINE ANXIETY RATINGS. PLACEBO CAUSED NO CHANGES IN BASELINE-CORRECTED BEHAVIORAL, CARDIOVASCULAR OR NEUROCHEMICAL RESPONSES IN EITHER GROUP. YOHIMBINE INDUCED A PANIC EPISODE IN 6 PATIENTS, BUT NO CONTROLS. PD PATIENTS HAD SIGNIFICANTLY HIGHER SEVERITY SCORES OF AUTONOMIC ANXIETY SYMPTOMS. YOHIMBINE SIGNIFICANTLY RAISED SYSTOLIC BLOOD PRESSURE, PLASMA NE LEVELS AND CORTISOL LEVELS, BUT HAD NO EFFECT ON EPINEPHRINE LEVELS. NE RESPONSES WERE SIMILAR IN BOTH GROUPS, BUT PATIENTS HAD HIGHER CORTISOL RESPONSES TO YOHIMBINE THAN CONTROLS. THE CORRELATIONAL PATTERN BETWEEN BEHAVIORAL RATINGS AND NEUROENDOCRINE RESPONSES IN PATIENTS WAS OPPOSITE TO THAT OBSERVED IN CONTROLS. DESPITE SIMILAR INCREASES IN PLASMA NE LEVELS BETWEEN PD PATIENTS AND HEALTHY CONTROLS, PD PATIENTS HAD GREATER ANXIOGENIC, CARDIOVASCULAR AND CORTISOL RESPONSES TO YOHIBINE. ENHANCED POST-SYNAPTIC ADRENORECEPTOR SENSITIVITY MAY EXPLAIN THE NORALDRENERGIC DYSREGULATION FOUND IN PANIC DISORDER. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |