Experiment 393485
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | SCHULZ,H: JOBERT,M:. (1994). EFFECTS OF HYPERICUM EXTRACT ON THE SLEEP EEG IN OLDER VOLUNTEERS.. 7(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY WAS CONDUCTED WITH 12 OLDER, HEALTHY VOLUNTEERS IN A CROSS-OVER DESIGN, WHICH INCLUDED A 2-WEEK WASH-OUT PHASE BETWEEN BOTH TREATMENT PHASES. A HYPOSTATIC INFLUENCE OF THE REM SLEEP PHASES, WHICH IS TYPICAL FOR TRICYCLIC ANTIDEPRESSANTS AND MAO INHIBITORS. INSTEAD, LI 160 INDUCED AN INCREASE OF DEEP SLEEP DURING THE TOTAL SLEEPING PEROID. THIS COULD BE SHOWN CONSISTENTLY IN THE VISUAL ANALYSIS OF THE SLEEPING PHASES AND 4, AS WELL AS IN THE AUTOMATIC ANALYSIS OF SLOW-WAVE EEG ACTIVITIES. THE CONTINUITY OF SLEEP WAS NOT IMPROVED BY LI 160; THIS WAS ALSO THE CASE FOR THE ONSET OF THE SLEEP, THE INTERMITTENT WAKE-UP PHASES, AND TOTAL SLEEP DURATION |
| Dose amount | 300.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |