Experiment 393524
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | BERGMANN,R: NUBNER,J: DEMLING,J:. (1993). TREATMENT OF MILD TO MODERATE DEPRESSION WITH HYPERICUM PERFORATUM AND AMITRIPTYLINE.. 7() |
| Amount utilized | |
| Compound isolated | |
| Disease | IN A DOUBLE-BLIND, RANDOMIZED STUDY, THE ANTIDEPRESSANT EFFICACY OF AN EXTRACT OF ST.JOHN'S WORT WAS COMPARED WITH AMITRIPTYLINE. THE STUDY POPULATION COMPRISED 80 MILDLY TO MODERATELY DEPRESSED PATIENTS BETWEEN 25 AND 83 YEARS. BOTH DRUGS EXHIBITED GOOD ANTIDEPRESSANT ACTIVITY WHICH INCREASED DURING THE COURSE OF THERAPY. IN RELATION TO BASELINE THE HAMD GLOBAL SCORE DROPPED BY ABOUT 60% IN THE HYPERICUM GROUP AND BY 56% IN THE TCA GROUP. THE BF-S SCORE ALSO DECLINED ON BOTH DRUGS. THE SUBJECTIVE FEELING OF DEPRESSION CORRELATED WITH THE OBJECTIVE IMPRESSION. AS REGARDS SIDE EFFECTS, THE PLANT-BASED ANTIDEPRESSANT HAD A CLEARLY MORE FAVOURABLE PROFILE. ON THERAPY WITH AMITRIPYTYLINE, GASTRIC SYMPTOMS, DRY MOUTH AND DAYTIME FATIGUE WERE MARKED, WHEREAS ONLY OCCASIONAL GASTRIC COMPLAINTS WERE OBSERVED WITH THE HYPERICUM MEDICATION. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |