Experiment 393528
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | LINDE,K: RAMIREZ,G: MULROW,CD: PAULS,A: WEIDENHAMMER,W: MELCHART,D:. (1996). ST JOHN'S FOR DEPRESSION - AN OVERVIEW AND META-ANALYSIS OF RANDOMISED CLINICAL TRIALS.. 313() |
| Amount utilized | |
| Compound isolated | |
| Disease | A META-ANALYSIS OF CONTROLLED CLINICAL TRIALS. 23 RANDOMISED TRIALS INCLUDING A TOTAL OF 1757 OUTPATIENTS WITH MAINLY MILD OR MODERATELY SEVERE DEPRESSIVE DISORDERS: 15 (14 TESTING SINGLE PREPARATIONS AND ONE A COMBINATION WITH OTHER PLANT EXTRACTS) WERE PLACEBO CONTROLLED, AND 8 (6 TESTING SINGLE PREPARATIONS AND TWO COMBINATIONS) COMPARED HYPERICUM WITH ANOTHER FRUG TREATMENT. -HYPERICUM EXTRACTS WERE SIGNIFICANTLY SUPERIOR TO PLACEBO (RATIO = 2.67; 95% CONFIDENCE INTERVAL 1.78 TO 4.01) AND SIMILARLY EFFECTIVE AS STANDARD ANTIDEPRESSANTS (SINGLE PREPARATIONS 1.10; 0.93 TO 1.31, COMBINATIONS 1.52; 0.78 TO 2.94). THERE WERE 2 (0.8%) DROP OUTS FOR SIDE EFFECTS WITH HYPERICUM AND 7 (3.0%) WITH STANDARD ANTIDEPRESSANT DRUGS SIDE EFFECTS OCCURRED IN 50 (19.8%) PATIENTS ON HYPERICUM AND 84 (52.8%) PATIENTS ON STANDARD ANTIDEPRESSANTS. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |