Experiment 393531
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | JOHNSON,D: KSCIUK,H: WOELK,H: SAUERWEIN-GIESE,E: FRAUENDORF,A:. (1994). EFFECTS OF HYPERICUM EXTRACT LI 160 COMPARED WITH MAPROTILINE ON RESTING EEG AND EVOKED POTENTIALS IN 24 VOLUNTEERS.. 7(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED DOUBLE-BLIND STUDY, THE EFFECT HYPERICUM EXTRACT WAS COMPARED TO THAT OF MAPROTILINE IN 24 HEALTHY VOLUNTEERS. THE INVESTIGATIONS INCLUDED MEASUREMENTS OF RESTING EEG AS WELL AS VISUAL AND ACOUSTIC EVOKED POTENTIALS. IN RESTING EEGS, BOTH MEDICATIONS REVEALED OPPOSITELY DIRECTED CHANGES IN THE THETA FREQUENCIES, AND MAINLY SIMILARLY DIRECTED CHANGES IN ALPHA AND BETA FREQUENCIES. MEASUREMENTS OF EVOKED POTENTIALS IN THE THETA AND BETA FREQUENCIES SUPPORTED THESE RESULTS. THE RESULTS INDICATE IMPROVED COGNITIVE FUNCTIONS MAINLY WITH THE TREATMENT OF HYPERICUM EXTRACT. |
| Dose amount | 900.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |