Experiment 393532
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | HILLER,KO: RAHLFS,V:. (1995). THERAPEUTISCHE AQUIVALENZ EINES HOCHDOSIERTEN PHYTOPHARMAKONS MIT AMITRIPTYLIN BEI ANGSTLICH DEPRESSIVEN VERSTIMMUNGEN-REANALYSE EINER RANDOMISIERTEN STUDIE UNTER BESONDERER BEACHTUNG BIOMETRISCHER UND KLINISCHER ASPEKTE.. 2() |
| Amount utilized | |
| Compound isolated | |
| Disease | RANDOMIZED, CONTROLLED DOUBLE-BLIND STUDY OVER 6 WEEKS. 153 OUTPATIENTS BETWEEN 20 AND 65 YEARS DIAGNOSED WITH DYSTHYMIA, SHORT OR LONGER LASTING DEPRESSIVE REACTIONS, NEUROASTHENIA OR NEUROTIC DEPRESSION. PATIENTS WERE TREATED EITHER WITH 150- 300 MG VALERIAN ROOT/ST.JOHN'S WORT CONCENTRATE (BJK) 3 TIMES DAILY (EQUIVALENT TO 0.45-0.9 MG TOTAL HYPERICIN) OR WITH 25-50 MG AMITRIPTYLINE 3 TIMES DAILY IN CAPSULES. HAMILTON DEPRESSION SCALE (HAMD), A GENERAL WELL BEING SCALE (BF-S) AND A SELF RATING SCALE FOR DEPRESSION 9SDS). 147 PATIENTS COMPLETED THE STUDY WITH 82% TREATMENT RESPONDERS IN THE PHYTOMEDICINE GROUP AND 77% RESPONDERS IN THE AMITRIPTYLINE GROUP. THE INITIAL TOTAL HAMILTON DEPRESSION SCORE WAS REDUCED FROM 24.3 TO 8.9 AFTER AMITRIPTYLINE. |
| Dose amount | VAR MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |