Experiment 393820
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Glycine max (FABACEAE) |
| Citation | ALBERTAZZI,P: PANSINI,F: BONACCROSI,G: ZANOTTI,L: FORINI,E: DE ALOYSIO,D:. (1998). THE EFFECT OF DIETARY SOY SUPPLEMENTATION ON HOT FLUSHES.. 91(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | A DOUBLE-BLIND, PARALLEL, MULTICENTER, RANDOMIZED PLACEBO-CONTROLLED TRIAL IN 104 POST-MENOPAUSAL WOMEN. FIFTY-ONE PTS (AGE RANGE 48-61 YRS) TOOK 60 G OF ISOLATED SOY PROTEIN DAILY AND 53 PTS (AGE RANGE 45-62 YRS) TOOK 60 OF PLACEBO (CASEIN) DAILY. THE STUDY LASTED 12 WEEKS. USING ANALYSIS OF COVARIANCE, WE ANALYZED CHANGES FROM BASELINE IN MEAN NUMBER OF MODERATE TO SEVERE HOT FLUSHES (INCLUDING NIGHT SWEATS) DURING TREATMENT. THE RESULTS DEMONSTRATED THAT: SOY WAS SIGNIFICANTLY SUPERIOR TO PLACEBO (P<.01 IN REDUCING THE MEAN NUMBER OF HOT FLUSHES PER 24 HRS AFTER 4, 8, AND 12 WKS OF TREATMENT. IN PATICULAR, WOMEN TAKING SOY HAD A 26% REDUCTION IN THE MEAN NUMBER OF HOT FLUSHES BY WEEK 3 AND A 33% REDUCTION BY WEEK 4 (P<.001 BY THE WILCOXON EXACT TEST). BY THE END OF THE 12TH WEEK, PTS TAKING SOY HAD A 45% REDUCTION IN THEIR DAILY HOT FLUSHES VERSUS A 30% REDUCITON OBTAINED WITH THE PLACEBO (P<.01). THE OVERRALL RATES OF ADVERSE EFFECTS WERE SIMILAR FOR SOY AND CASEIN-PLACEBO. TWENTY-FIVE PTS DROPPED OUT OF THE STUDY: 11 IN THE SOY GROUP AND 14 IN THE PLACEBO GROUP. GASTROINTESTINAL SIDE EFFECTS WERE THE MOST COMMON CAUSE OF PREMATURE WITHDRAWAL FROM THE STUDY (SEVEN PTS IN EACH GROUP). SOY PROTEIN ISOLATED ADDED DAILY TO THE DIET SUBSTANTIALLY REDUCED THE FREQUENCY OF HOT FLUSHES IN CLIMACTERIC WOMEN. |
| Dose amount | 60.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | SEEDS |
| Gender | FEMALE |