Experiment 393883
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | BLUME,J: KIESER,M: HOLSCHER,U:. (1996). PLACEBO-CONTROLLED, DOUBLE-BLIND STUDY ON GINKGO BILOBA SPECIAL EXTRACT EGB 761 IN TRAINED PATIENTS WITH INTERMITTENT CLAUDICATION.. 2() |
| Amount utilized | |
| Compound isolated | |
| Disease | A MONOCENTER, RANDOMIZED, PLACEBO-CONTROLLED DOUBLE-BLIND STUDY WITH PARALLEL-GROUP COMPARISON WAS CARRIED OUT IN ORDER TO DEMOONSTRATE THE EFFICACY OF GINKGO BILOBA SPECIAL EXTRACT EGB 761 ON OBJECTIVE AND SUBJECTIVE PARAMETERS OF THE WALKING PERFORMANCE IN TRAINED PATIENTS SUFFERING FROM PERIPHERAL ARTERIAL OCCLUSLIVE DISEASE IN FONTAINE STAGE 11B. IN TOTAL 60 PATIENTS WERE RECRUITED (42 MEN; AGED 7-82 YRS). WITH ANGIOGRAPHICALLY PROVEN PERIPHERAL ARTERIAL OCCLUSIVE DISEASE OF THE LOWER EXTREMITITES AND AN INTERMITTENT CLAUDICATION EXISTING FOR AT LEAST 6 MONTHS. NO IMPROVMENT HAD BEEN SHOWEN DESPITE CONSISTENT WALKING TRAINING AND A MAXIMUM PAIN-FREE WALKING DISTANCE ON THE TREADMILL OF LESS THAN 150 M WAS RECORDED AT THE BEGINNING OF THE STUDY. THE THERAPEUTIC GROUPS WERE TREATED WITH EITHER GINKGO BILOBA SPECIAL EXTRACT EGB 761 AT A DOSE OF 3 TIMES 1 FILM-COATED TABLET OF 40 MG PER DAY BY ORAL ROUTE OR PLACEBO OVER A DURATION OF 24 WKS FOLLOWING A TWO-WK PLACEBO RUN IN PHASE. THE MAIN OUTCOME MEASURE WAS THE DIFFERENCE OF THE WALKING DISTANCE BETWEEN THE START OF TREATMENT AND AFTER 8, 16 AND 24 WKS OF TREATMENT AS MEASURED ON THE TREADMILL (WALKING SPEED 3 KM/H AND SLOPE OF 12%). GINKGO BILOBA SPECIAL EXTRACT EG6 761 PRODUCES A STATISTICALLY HIGHLY SIGNIFICANT AND CLINICALLY RELEVANT IMPROVEMENT OF THE WALKING PERFORMANCE IN TRAINED PATIENTS SUFFERING FROM INTERMITTENT CLAUDICAITON WITH VERY GOOD TOLERANCE OF THE STUDY PREPARATION. |
| Dose amount | 120.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(100%)EXT |
| Gender | GIVEN TO BOTH SEXES |