Experiment 394371

Worktypes

Details

Property	Value
Pharmacology	WEIGHT LOSS
Administration route	ORAL
Organism	Garcinia cambogia (CLUSIACEAE)
Citation	HEYMSFIELD,SB: ALLISON,DB: VASSELLI,JR: PIETROBELLI,A: GREENFIELD,D: NUNEZ,C:. (1998). GARCINIA CAMBOGIA (HYDROXYCITRIC ACID) AS A POTENTIAL ANTIOBESITY AGENT.. 280(18)
Amount utilized
Compound isolated
Disease	EVALUATION ON THE EFFICACY OF G. CAMBOGIA FOR BODY WEIGHT AND FAT MASS LOSS IN OVERWEIGHT HUMAN SUBJECTS IN A 12-WEEK RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. OVERWEIGHT MEN AND WOMEN SUBJECTS (MEAN BODY MASS INDEX[WEIGHT IN KILOGRAMS DIVIDED BY THE SQUARE OF HEIGHT IN METERS], APPROXIMATELY 32 KG/M. SUBJECTS WERE RANDOMIZED TO RECEIVE EITHER ACTIVE HERBAL COMPOUND (1500 MG OF HYDROXYCITRIC ACID PER DAY) OR PLACEBO, AND BOTH GROUPS WERE PERSCRIBED A HIGH-FIBER, LOW-ENERGY DIET. THE TREATMENT PEROID WAS 12 WEEKS. BODY WEIGHT WAS EVALUATED EVERY OTHER WEEK AND FAT MASS WAS MEASURED AT WEEKS 0 AND 12. THE MAIN OUTCOME MEASURES WERE BODY WEIGHT CHANGE AND FAT MASS CHANGE. A TOTAL OF 135 SUBJECTS WERE RANDOMIZED TO EITHER ACTIVE HYDROXYCITRIC ACID (N = 66) OR PLACEBO (N = 69); 42 (64%) IN THE ACTIVE HYDROXYCITRIC ACID GROUP AND 42 (61%) IN THE PLACEBO GROUP COMPLETED 12 WEEKS OF TREATMENT (P = .74). PATIENTS IN BOTH GROUPS LOST A SIGNIFICANT AMOUNT OF WEIGHT DURING THE 12-WEEK TREATMENT PERIOD (P<.001); HOWEVER, BETWEEN-GROUP WEIGHT LOSS DIFFERENCES WERE NOT STATISTICALLY SIGNIFICANT (MEAN[SD], 3.2[3.3] KG VS 4.1 [3.9]KG; P = .14). THERE WERE NO SIGNIFICANT DIFFERENCES IN ESTIMATED PERCENTAGE OF BODY FAT MASS LOSS BETWEEN TRETMENT GROUPS, AND THE FRACTION OF SUBJECT WEIGHT LOSS AS FAT WAS NOT INFLUENCED BY TREATMENT GROUP. GARCINIA CAMBOGIA FAILED TO PRODUCE SIGNIFICANT WEIGHT LOSS AND FAT MASS LOSS BEYOND THAT OBSERVED WITH PLACEBO.
Dose amount	3.0 GM
Number	1
Qualitative result	INACTIVE
Animal	HUMAN ADULT
Per unit	DAY
Dose expression	DOSE
Extract	TYPE EXT NOT STATED
Gender	GIVEN TO BOTH SEXES