| Disease | THE PHARMACOKINETICS OF GINKGOLIDE A. GINKGOLIDE B AND BILOBALIDE, WHICH ARE COMPOUNDS EXTRACTED FROM THE DRIED LEAVES OF THE GINKGO BILOBA TREE, WERE INVESTIGATED IN 12 YOUNG HEALTHY VOLUNTEERS (SIX MEN AND SIX WOMEN: MEAN +/- SD AGE = 25 +/-
YEARS) AFTER SINGLE-DOSE ADMINISTRATION OF GINKGO BILOBA EXTRACT. SUBJECTS WERE GIVEN, ON THREE OCCASIONS. GINKGO BILOBA EXTRACT AS A SOLUTION EITHER ORALLY (IN FASTING CONDITIONS AND AFTER A STANDARD MEAL) OR INTRAVENOUSLY; CORRESPONDING TO
SINGLE DOSES OF GINKGOLIDE A, GINKGOLIDE B AND BILOBALIDE RANGING FROM 0.90 MG TO 3.36 MG. WHEN GIVEN ORALLY, WHILE FASTING, THE EXTENTS OF BIOAVAILABILITY ARE HIGH, AS SHOWN BY BIOAVAILABILITY COEFFICIENTS (FACE) MEAN +/- SD) VALUES EQUAL TO
0.80 E(+/- 0.09). 0.88 (+/- 0.21) AND 0.79 (+/- 0.30) FOR GINKGOLIDE A. GINKGOLIDE B AND BILOBALIDE RESPECTIVELY. FOOD INTAKE DOSE NOT CHANGE AUC QUANTITATIVELY BUT INCREASES T-MAN FOR THE THREE COMPOUNDS OF INTEREST, AFTER ORAL DOSING WHILE
FASTING, DIFFERENCES CAN BE NOTED FOR THE ELIMINATION HALF-LIVES (T 1 2 Z), WHILE EXHIBIT MEAN VALUES EQUAL TO 4.50, 10.57 AND 3.21 H. AS WELL AS MEAN RESIDENCE TIMES (MRT). EQUAL TO 5.86. 11.25 AND 1.89 H. FOR GINKGOLIDE A. GINKGOLIDE B AND
BILOBALIDE RESPECTIVELY. SUCH VALUES SUGGEST THAT GINKGO BILOBA EXTRACT (EGB 761) COULD BE GIVEN TWICE DAILY IN MULTIPLE ORAL DOSING. |