Experiment 394726
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | SCHUBERT,H: HALAMA,P:. (1993). DEPRESSIVE EPISODE PRIMARILY UNRESPONSIVE TO THERAPY IN ELDERLY PATIENTS: EFFICACY OF GINKGO BILOBA EXTRACT EGB 761 IN COMBINATION WITH ANTIDEPRESSANTS.. 1993(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN A RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND STUDY 40 PATIENTS AGED 51-78 YEARS WERE STUDIED. THE PATIENTS SUFFERED FROM MILD TO MODERATE CEREBRAL DYSFUNCTION COMBINED WITH DEPRESSIVE EPISODES SHOWING INSUFFICIENT RESPONSE TO A TREATMENT WITH THE ANTIDEPRESSANTS WAS COMBINED IN TWENTY PATIENTS WITH DAILY DOSES OF 3 X 80 MG OF THE STANDARDIZED GINKGO BILOBA SPECIAL EXTRACT EGB 761 (FILM COATED TABLETS) OR WITH PLACEBO. THE SUM SCORE OF THE HAMILTON DEPRESSION SCALE (HAMD) WAS CHOSEN AS THE KEY PARAMETER OF CONFIRMATORY STATISTICAL ANSLYSIS. IN PATIENTS TREATED ADDITIONALLY WITH EGB 761 ALREADY AFTER 4 WEEKS A DECLINE TO 4.5 AT THE END OF THE STUDY. IN THE PLACEBO GROUP THE MEDIAN TOTAL SCORE SHOWING AN IDENTICAL INITIAL VALUE DECREASE ONLY BY ONE POINT AND THEN MAINTAINED THE SAME OVER THE STUDY PERIOD. THE THERAPUTIC SUPIERIORITY OF EGB 761 VS. PLACEBO WAS HIGHLY SIGNIFICANT AFTER 4 WEEKS (P=0.001) AND 8 WEEKS (PZ0.01) OF TREATMENT, RESPECTIVELY. ALSO A SIGNIFICANT IMPROVEMENT IN COGNITIVE FUNCTIONS WAS DEMONSTRATED. |
| Dose amount | 240.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(100%)EXT |
| Gender | GIVEN TO BOTH SEXES |