Experiment 394790
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | BRUCHER,E: HEINRICH,SE: RUF-KOHLER,P:. (1991). WIRKSAMKEIT VON L1 1370 BEI ALTEREN PATIENTEN MIT HIRN-LEISTUNGSSCHWACH. MULTIZENTRICHE DOPPELBLINDSTUDIE DES FACHVERBANDES DEUTSCHER ALLGEMEINARZTE.. 133(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | A PLACEBO-CONTROLLED DOUBLE-BLIND STUDY CONCERNING THE EFFICACY OF A GINKGO BILOBA SPECIAL EXTRACT IN ELDERLY PATIENTS WITH CEREBRAL INFUFFICIENCY WAS CARRIED OUT WITH 303 OUTPATIENTS. THE DOSAGE WAS 3 X 1 COATED TABLETS OF 50 MG GINKGO BILOBA SPECIAL EXTRACT DAILY FOR 12 WEEKS. CONTROLS LOOK PLACE AFTER THE 6TH AND 12TH THERAPY WEEK. SIGNS OF CEREBRAL INSUFFRICIENCY AS WELL AS THE FIGURE CONNECTION TEST AND AT THE END OF THE THERAPY THE DOCTOR'S AND PATIENT'S JUDGEMENT ON THE EFFICACY OF THE PREPARATION WERE TAKEN INTO ACCOUNT. 209 PROTOCOLS WERE AVAILABLE FOR THE STATISTICAL EVALUATION. STATISTICALLY SIGNIFICANT IMPROVEMENTS WERE DEMOSTRATED AFTER 6 WEEKS OF THERAPY ON 3 OUT OF 11 TYPICAL SYMPTOMS AND AFTER 12 WEEKS OF THERAPY ON 8 OUT 11. IN THE ACTIVE GROUP THE TIME PERIOD FOR THE FIGURE CONNECTION TEST WAS IMPROVED BY 25%, IN THE PLACEBO GROUP ONLY 14% (P<0.01 IN COMPARISON BETWEEN THE GROUPS). BOTH THE DOCTRO'S AND THE PATIENT'S JUDGEMENT CONCERNING THE EFFICACY SHOW HIGHLY SIGNIFICANT DIFFERENCES BETWEEN THE TWO GROUPS. THE INCIDENCE OF SIDE EFFECTS WAS AS HALF AS HIGH IN THE VERUM GROUP COMPARED TO THE PLACEBO GROUP. EGB-761 WAS USED. |
| Dose amount | 150.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(100%)EXT |
| Gender | GIVEN TO BOTH SEXES |