Experiment 395079
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Serenoa repens (ARECACEAE) |
| Citation | TIMMERMANS,LMJ: TIMMERMANS JR,LGJ:. (1990). THE MEASURE OF THE ACTIVITY OF THE ECHINACEAE AND SABALE EXTRACTS IN THE TREATMENT OF THE FEMALE IDIOPATHIC HYPOTONIC BLADDER.. 58(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | 30 PATIENTS (25 TO 76 YEARS OLD); SUFFERING FROM INCONTIENCE (18); POLLAKIURIA (6) AND DYSURIA (6) REVEAL AT THE EURODYAMIC INVESTIGATION (UROVIDEO 2100 AND NEUROMATIC 2000M) AN IDIOPATHIC LARGE HYPOTONIC BLADDER. 20 HAVE BEEN TREATED BY ECHINACEA (84 TO 112 MG/A DAY) AND SABALAE (78 TO 104 MG/A DAY) EXTRACTS DURING A MEAN TIME OF 77 DAYS. 10 HAVE RECEIVED 90 TO 120 DROPS/A DAY OF A PLACEBO DURING A MEAN TIME OF 52 DAYS. AFTER PLACEBO NO MODIFICATION OF THE SYMPOMATOLOGY AND NO SIGNIFICANT DIFFERENCE IN THE MEASURES HAVE BEEN REGISTERED. AFTER URGENIN: THE BLADDER CAPACITY, THE RESIDUAL URINE AND THE COMPLIANCE ARE SIGNIFICANTLY DECREASED; THE DETRUSOR PRESSURE AND THE PEAK FLOW ARE SIGNIFICANTLY INCREASED. THE URETRAL PRESSURE, THE CLOSURE PRESSURE AND THE URETRAL INSTABILITY SHOW A NON-SIGNIFICANT DECREASE. THE MODIFICATIONS OF THE PROFILOMETERS AND SPHINCTER EMG ARE NOT SIGNIFICANT. IN TWO CASES BILATERAL VESICO-RENTAL REFLUXES HAVE DISAPPEARED. THE RESULT OF THE STUDY SUGGEST THAT THE NEUROTRANSMISSION IF FACILITED AND THAT THE SMOOTH MUSCLE FIBER IS ACTIVATED BY URGENIN. THEY MEASURE THE POSITIVE ACTIVITY OF ECHINACEAE AND SABALAE EXTRACTS IN THE TREATMENT OF FEMALE IDIOPATHIC LARGE HYPOTONIC BLADDERS. |
| Dose amount | 104.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | FEMALE |