Experiment 397329
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | RAABE,A: RAABE,M: IHM,P:. (1991). THERAPY MONITORING WITH AUTOMATED PERIMETRY IN ELDERLY PATIENTS SUFFERING FROM CHRONIC CEREBRORETINAL INSUFFICIENCY. A DOUBLE-BLIND STUDY WITH GRADUATED DOSES OF EGB 761.. 199() |
| Amount utilized | |
| Compound isolated | |
| Disease | A DOUBLE-BLIND STUDY IN ELDERLY PATIENTS WITH CHRONIC CEREBRORETINAL INSUFFRICIENCHY. USING AUTOMATED PERIMETRY. MEASUREMENTS WERE MADE WITH THIS METHOD ON 24 PATIENTS (4 MEN AND 20 WOMEN WITH AGE OF 74.9 + 6.9 YEARS). THE EFFECT OF THE EXTRACT OF GINKGO BILOBA (EGB 761) ON THE REVERSIBILITY OF VISUAL FIELD DISTURBANCES WAS TESTED USING A RANDOMIZED AND DOUBLE BLIND STUDY-DESIGN IN TWO PHASES AND WITH TWO DOSE LEVEVLS. THE MAIN PARAMETER INVESTIGATED IN THIS STUDY WAS THE CHANGE IN THE LUMINOUS DENSITY DIFFERENCE THRESHHOLD AFTER THERAPY WITH EGB 761. IN GROUP B (EGB 761 DOSE 160 MG/DAY) A SIGNIFICANT INCREASE IN RETINAL SENSITIVITY WAS SEEN WITH 4 WEEKS (P<0.05). IN THE LOWER DOSE (80 MG EGB 761/DAY) GROUP (A), THIS CHANGE IN RETINAL SENSITIVITY WAS FIRST SEEN AFTER INCREASING THE DOSE TO 160 MG/DAY (P<0.01). THE RELATIVE SENSITIVITY OF DAMAGE RETINAL AREAS WAS MORE STR4ONGLY INFLUENCE THAN HEALTHY AREAS. THE ASSESSMENT BY BOTH DOCTORS AND PATIENTS OF THE GENERAL CONDITION OF THE PATIENTS SHOWED A SIGNIFICANT IMPROVEMENT AFTER THE COURSE OF THERAPY. THE RESULTS PRESENTED HERE SHOW THAT DAMAGE TO THE VISUAL FIELD BY CHRONIC LACK OF FLOODFLOW ARE SIGNIFICANTLY REVERSIBLE. A COMMERCIAL PRODUCT, EGB-761, WAS USED. |
| Dose amount | 160.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(100%)EXT |
| Gender | GIVEN TO BOTH SEXES |