Experiment 398118
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | LETZEL,H: SCHOOP,W:. (1992). GINKGO BILOBA EXTRACT EGB 761 AND PENTOXIDYLLINE IN INTERMITTENT CLAUDICATION. SECONDARY ANALYSIS OF CLINICAL EFFICACY STUDIES.. 21(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE METHODS AND RESULTS OF CLINICAL STUDIES ON THE EFFICACY OF EGB 761 AND OF PENTOXIFYLLINE ARE SUMMARIZED AND COMPARED. ALL PLACEBO-ROLLED, RANDOMIZED, DOUBLE-BLIND STUDIES WITH "PAIN-FREE WALKING DISTANCE' AS THE MAIN TARGET CRITERION WERE SELECTED. THE PENTOXIFYLLINE STUDIES WERE CARRIED OVER FROM AN EARLIER REVIEW OF THE ENGLISH-LANGUAGE LIGTERATURE, WHICH WAS UPDATED BY A DIMDI SEARCH. THE STUDIES ON BOTH DRUGS SUFFER FROM THE SAME METHODOLOGICAL DIFFICULTIES, AND THERE IS NO DIFFERENCE BETWEEN THEM IN RESPECT OF QUALITY. THE INCREASE IN THE WALKING DISTANCE VARIES VERY WIDELY, PARTICULARLY IN THE PENTOXIFYLLINE STUDIES. WHEN THE RESULTS ARE AVERAGED OVER ALL STUDIES FOR EACH OF THE PREPARATIONS, THE RELATIVE INCREASE EXPRESSED IN RELATION TO THE BASELINE VALUE IS FOUND TO BE 45% FOR EGB 761 AND 57% FOR PENTOXIFYLLINE. NO DIFFERENCES IN THE DOCUMENTATION OF EFFICACY OR IN CLINICAL EFFICACY WERE FOUND BETWEEN THE TWO SUBSTANCES. A COMMERCIAL PRODUCT, EGB-761, WAS USED. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | ETOH(100%)EXT |
| Gender | GIVEN TO BOTH SEXES |