Experiment 399868
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Plantago ovata (PLANTAGINACEAE) |
| Citation | MC RORIE,JW: DAGGY,BP: MOREL,JG: DIERSING,PS: MINER,PB: ROBINSON,M:. (1998). PSYLLIUM IS SUPERIOR TO DOCUSATE SODIUM FOR TREATMENT OF CHRONIC CONSTIPATION.. 12(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | MULTI-SITE RANDOMIZED DOUBLE-BLIND PARALLEL-DESIGN STUDY OF 170 SUBJECTS WITH CHRONIC IDIOPATHIC CONSTIPATION INVOLVED A 2-WEEK BASELINE (PLACEBO) PHASE FOLLOWED BY 2 WEEKS OF TREATMENT. THE TREATMENT PHASE COMPARED PSYLLIUM (5.1 G BID.) PLUS DOCUSATE PLACEBO TO DOCUSATE SODIUM (100 MG BID.) PLUS PSYLLIUM PLACEBO. STOOLS WERE COLLECTED AND ASSESSED. COMPARED BASELINE, PSYLLIUM INCREASED STOLL WATER CONTENT VS. DOCUSATE (PSYLLIUM 2.33% VS. DOCUSATE 0.01%. P = 0.007). PSYLLIUM ALSO INCREASED STOOL WATER WEIGHT TOTAL STOOL OUTPUT. AND O'BRIEN RANK-TYPE SCORE COMBINING OBJECTIVE MEASURES OF CONSTIPATION. BOWEL MOVEMENT (BM) FREQUENCY WAS SIGNIFICANTLY GREATER FOR PSYLLIUM (3.5 BM/WEEK) VS. DOCUSATE (2.9 BM/WEEK) IN TREATMENT WEEK 2 (P = 0.02). WITH NO SIGNIFICANT DIFFERENCE (P > 0.05) BETWEEN TREATMENT GROUPS IN TREATMENT WEEK 1(3.3 VS.3.1 BM/WEEK). |
| Dose amount | 11.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HUSKS |
| Gender | GIVEN TO BOTH SEXES |