Experiment 401466

Property	Value
Pharmacology	BIOAVAILABILITY OF
Administration route	INTRAGASTRIC
Organism	Hypericum perforatum (CLUSIACEAE)
Citation	BIBER,A: FISCHER,H: ROMER,A: CHATTERJEE,SS:. (1998). ORAL BIOAVAILABILITY OF HYPERFORIN FROM HYPERICUM EXTRACTS IN RATS AND HUMAN VOLUNTEERS.. 31(1)
Amount utilized
Compound isolated
Disease	AFTER ORAL ADMINISTRATION OF 300 MG/KG HYPERICUM EXTRACT (WS5572, CONTAINING 5% HYPERFORIN) TO RATS MAXIMUM PLASMA LEVELS OF APPROXIMATELY 370 NG/ML (APPROX. 690 NM) WERE REACHED AFTER 3 H, AS QUANTIFIED BY A HPLC AND UV DETECTION METHOD. ESTIMATED HALF-LIFE AND CLEARANCE VALUES WERE 6 H AND 70 ML/MIN/KG RESPECTIVELY.
Dose amount	300.0 MG
Number	2
Qualitative result	.
Animal	RAT
Per unit	PERSON
Dose expression	DOSE
Extract	HYDRO-ALCOHOLIC EXT
Gender	MALE