Experiment 401467
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | BIBER,A: FISCHER,H: ROMER,A: CHATTERJEE,SS:. (1998). ORAL BIOAVAILABILITY OF HYPERFORIN FROM HYPERICUM EXTRACTS IN RATS AND HUMAN VOLUNTEERS.. 31(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE MAXIMUM PLASMA LEVELS OF APPROXIMATELY 150 NG/ML (APPROX. 280 NM) WERE REACHED 3.5 H AFTER ADMINISTRATION. HALF-LIFE AND MEAN RESIDENCE TIME WERE 9 AND 12 H RESPECTIVELY. HYPERFORIN PHARMACOKINETICS WERE LINEAR UP TO 600 MG OF THE EXTRACT INCREASING THE DOSES TO 900 OR 1200 MG OF EXTRACT RESULTED IN LOWER CMAX AND AUC VALUES THAN THOSE EXPECTED FROM LINEAR EXTRAPOLATION OF DATA FROM LOWER DOSES. PLASMA CONCENTRATION CURVES IN VOLUNTEERS FITTED WELL IN AN OPEN TWO-COMPARTMENT MODEL. IN A REPEATED DOSE STUDY, NO ACCUMULATION OF HYPERFORIN IN PLASMA WAS OBSERVED. USING THE OBSERVED AUC VALUES FROM THE REPEATED DOSE STUDY, THE ESTIMATED STEADY STATE PLASMA CONCENTRATIONS OF HYEPRFORIN AFTER 3 X 300 MG/DAY OF THE EXTRACT, 1.E., AFTER NORMAL THERAPEUTIC DOSE REGINMEN, WAS APPROXIMATELY 100 NG/ML (APPROX. 180NM). |
| Dose amount | 300.0 MG |
| Number | 3 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |