Experiment 417260
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | BISSETT,D: GRAHAM,MA: SETANOIANS,A: CHADWICK,GA: WILSON,P: KOIER,I: HENRAR,R: SCHWARTSMANN,G: CASSIDY,J: KAYE,SB: KERR,DJ:. (1992). PHASE I AND PHARMCOKINETIC STUDY OF RHIZOXIN.. 52(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | 24 PATIENTS WITH VARIOUS TUMOR TYPES WERE TREATED IN THIS PHASE 1 STUDY. PATIENTS WERE TREATED WITH DOSES RANGING FROM 0.8 TO 2.6 MG/M2 ONCE EVERY 3 WEEKS UNTIL WITHDRAWAL FROM THE STUDY. THE MOST SEVERE TOXICITIES INCLUDED MUCOSISTS, LEUKOPENIA AND DIARRHEA. OTHER TOXICITIES INCLUDED ALOPECIA, DISCOMFORT AT INJECTION SITE, PERIPHERAL NEUROPATHY, PHLEBITIS, NAUSEA AND VOMITING. PHARMACOKINETIC STUDY SHOWED THE DRUG WAS NOT DETECTABLE AT DOSES OF 0.8 MT/M2 AND 1.6 MG/M2 AND NOT MEASUREABLE 10 MINUTES AFTER INJECTION AT 2.0 MG/M2. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |