Experiment 417431
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | SAROSY,G: KOHN,E: STONE,DA: ROTHENBERG,M: JACOB,J: ADAMO,DO: OGNIBENE,FP: CUNNION,RE: REED,E:. (1992). PHASE I STUDY OF TAXOL AND GRANULOCYTE COLONY-STIMULATING FACTOR IN PATIENTS WITH REFRACTORY OVARIAN CANCER.. 10(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | 15 PATIENTS WITH PLATINUM-REFRACTORY OR RECURRENT ADVANCED-STAGE OVARIAN CANCER WERE USED IN THIS PHASE 1 STUDY. TAXOL WAS ADMINISTERED IN DOSES OF 170, 200, AND 300 MG/M2 PER CYCLE; THEY WERE GIVEN EVERY 3 WEEKS. DOSE LIMITING TOXICITY WAS PERIPHERAL NEUROPATHY PRIMARILY MANIFESTED BY A STOCKING AND GLOVE SENSORY DISTURBANCE AFFECTING PROPRIOCEPTION. MYELOSUPPRESSION WAS OBSERVED, BUT WAS NOT DOSE-LIMITING. 14 PATIENTS OUT OF 15 WERE ASSESSABLE FOR RESPONSE TO THERAPY. 1 PATIENT SHOWED COMPLETE RESPONSE AND 4 PATIENTS SHOWED PARTIAL RESPONSE. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |