Experiment 418139
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Symphytum uplandicum (BORAGINACEAE) |
| Citation | YEONG,ML: CLARK,SP: WARING,JM: WILSON,RD: WAKEFIELD,J:. (1991). THE EFFECTS OF COMFREY DERIVED PYRROLIZIDINE ALKALOIDS ON RAT LIVER.. 23() |
| Amount utilized | |
| Compound isolated | |
| Disease | SIGNS OF TOXICITY INCLUDED SWELLING OF HEPATOCYTES AND HEMORRHAGIC NECROSIS OF PR=ERIVENULAR CELLS. THERE WAS ALSO LOSS OF SINUSODIAL LINING OF CELLS WITH DISRUPTION OF SINUSODIAL WALL AND SINUSOIDS WERE FILLED WITH CELLULAR DEBRIS, HEPATOCYTE ORGANELLES AND RED BLOOD CELLS. |
| Dose amount | 200.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | ALKALOID FRACT |