Experiment 420986
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | JIN,GZ: HUANG,KX: SUN,BC:. (1992). DUAL ACTIONS OF (-)-STEPHOLIDINE ON DOPAMINE RECEPTOR SUBTYPES AFTER SUBSTANTIA NIGRA LESION.. 20() |
| Amount utilized | |
| Compound isolated | |
| Disease | IN 6-OHDA-LESIONED ANIMALS, COMPOUND HAD A LATENT PEROID AND A MAXIMAL RESPONSE AT 63 DAYS. DURING LATENCY, IT ANTAGONIZED EFFECT OF APOMORPHINE, WHILE DURING ITS PERIOD OF FULL RESPONSE ITS POTENTIATED APOMORPHINE-INDUCED ROTATION. IN ANIMALS LESIONED WITH BOTH KAINIC ACID AND B-OHDA, COMPOUND ANTAGONIZED THE RESPONSE TO APOMORPHINE. DI RECEPTORS INVSUBST. NIGRA ARE PROBABLY RESPONSIBLE FOR COMPOUND'S AGONIST ACTIVITY. |
| Dose amount | 4.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |