Experiment 421145
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | MARKMAN,M: ROWINSKY,E: HAKES,T: REICHMAN,B: JONES,W: LEWIS JR,JL: RUBIN,S: CURTIN,J: BARAKAT,R: PHILLIPS,M: HUROWITZ,L: ALMADRONES,L: HOSKINS,W:. (1992). PHASE I TRIAL OF INTRAPERITONEAL TAXOL: A GYNECOLOIC ONCOLOGY GROUP STUDY.. 10(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | 25 PATIENTS WERE ENTERED INTO THIS PHASE ONE STUDY. 24 PATIENTS HAD OVARIAN CANCER AND 1 PATIENT HAD BREAST CANCER. PATIENTS WERE DOSED EVERY 3-4 WEEKS. TOXICITIES INCLUDED BONE MARROW SUPPRESSION, WBC COUNT DECREASE, NEUTROPENIC FEVERS, SKIN RASHES WITH DOSE LIMITING TOXICITY OF ABDOMINAL PAIN. 2 PATIENTS EXHIBITED COMPLETE DISAPPEARANCE OF SIGNIFICANT PRETREATMENT ASCITES. 6 PATIENTS HAD SIGNIFICANT REDUCTIONS IN SERUM CA-125 ANTIGEN. |
| Dose amount | >175 MG |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Per unit | SQ M |
| Dose expression | DOSE |