Experiment 421257

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismTripterygium wilfordii (CELASTRACEAE)
CitationHUANG,H:. (1982). CLINICAL ANALYSIS OF 31 TOXICATION CASES BY USING TRIPTERYGIUM WILFORDII.. 21(6)
Amount utilized
Compound isolated
DiseaseTHIS IS A REPORT ON 31 CASES OF POISONING BY TRIPTERYGIUM WILFORDII. CLINICAL SYMPTOMS INCLUDED LOSS OF ENERGY (17 CASES), DIZZINESS (16 CASES), FEVER,(12 CASES), NAUSEA (12 CASES), VOMITING (19 CASES), ABDOMINAL PAIN (19 CASES), DIARRHEA (4 CASES), BACK PAIN (10 CASES), AND DECREASED URINATION (14 CASES). IN SEVERE CASES, BODY TEMPERATURE WAS OVER 40 C AND PATIENTS VOMITED BROWNISH BLOODY MATERIAL. IN VICTIMS INGESTING MORE THAN SEVEN YONG SHOOTS OF THE PLANT, BLOOD PRESSURE STARTED TO DECREASE WITHIN 3 DAYS. AFTER APPROPRIATE TREATMENT, THE PRESSURE INCREASED FOLLOWED BY EDEMA. AT EXTREMELY HIGH DOSES (48 SHOOTS OR MORE), SHOCK OCCURRED WITHIN 12 HOURS, FOLLOWED BY COMA AND RESPIRATORY DEPRESSION. TOXICITY AND DEATH ARE CAUSED BY KIDNEY DAMAGE. INTERNAL BLEEDING WAS OFTEN OBSERVED.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractPLANT