Experiment 421946
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | STEIN,RC: JOSEPH,AEA: MATLIN,SA: CUNNINGHAM,DC: FORD,HT: COOMBES,RC:. (1992). A PRELIMINARY CLINICAL STUDY OF GOSSYPOL IN ADVANCED HUMAN CANCER.. 30(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | 20 PATIENT WITH ADVANCED CANCER WERE TREATED ONCE WEEKLY AT DOSES RANGING FROM 30-180 MG FOR 1 TO 21 WEEKS IN THIS PHASE 1 STUDY. THE MEDIAN LIMITING DOSE FOR DAILY TREATMENT WAS 30 MG DAILY AND 120 MG WEEKLY. TOXIC SIDE EFFECTS INCLUDED EMESIS, DIARRHEA AND LETHARGY. NO DISTURBANCES OF HEMATOLOGICAL OR BIOCHEMICAL PARAMETERS WERE NOTED. NONE OF THE PATIENTS SHOWED EVIDENCE OF TUMOR REGRESSION. ALL ASSESSABLE PATIENTS DEVELOPED PROGRESSIVE DISEASE. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |