Experiment 425007
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN RATION |
| Organism | Empty organism |
| Citation | FUKUSHIMA,S: TANAKA,H: ASAKAWA,E: KAGAWA,M: YAMAMOTO,A: SHIRAI,T:. (1992). CARCINOGENICITY OF URACIL, A NONGENOTOXIC CHEMICAL, IN RATS AND MICE AND ITS RATIONALE.. 52(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | SIX WEEKS OLD F344 ANIMALS WERE FED GIVEN DIET FOR 104 WEEKS. ALMOST ALL MALES AND 30% OF FEMALES HAD URINARY BLADDER STONES. 90% OF MALES AND 19% OF FEMALES DEVELOPED TRANSITION CELL CARCINOMA. 10% OF MALES AND NO FEMALES DEVELOPED AND SQUAMOUS CELL CARCINOMA OF BLADDER. CONTROLS DEVELOPED NONE. PELVIS TUMORS OCCURRED WITH INCREASED INCIDENCE IN TREATED ANIMALS, 13% OF MALES DEVELOPING PAPILLOMA AND 23% OF MALES AND 11% OF FEMALES DEVELOPING CARCINOMA COMPARED TO NO TUMORS IN CONTROLS. THE ADDITION OF NACL TO DIET HAD A PROTECTIVE EFFECT BY INDUCING POLYURIA SO THAT NO URINARY CALCULI WERE FORMED. |
| Dose amount | 3.0 % OF DIET |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |