Experiment 427767
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | SOLARY,E: CAILLOT,D: CHAUFFERT,B: CASASNOVAS,RO: DUMAS,M: MAYNADIE,M: GUY,H:. (1992). FEASIBILITY OF USING QUININE, A POTENTIAL MULTIDRUG RESISTANCE-REVERSING AGENT, IN COMBINATION WITH MITOXANTRONE AND CYTARABINE FOR THE TREATMENT OF ACUTE LEUKEMIA.. 10(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | 15 ADULTS WITH RELAPSED/REFRACTORY ACUTE LEUKEMIA WERE TREATED WITH COMPOUND CONCURRENTLY GIVEN WITH CYTARABINE AND MITOXANTRONE. 8 OF 14 ASSESSABLE PATIENTS HAD COMPLETE REMISSION, 2 HAD PARTIAL REMISSION. ALL THOSE WHOSE LEUKEMIA CELLS EXPRESSED P-GLYCOPROTEIN HAD SOME RESPONSE. TOXIC SIDE-EFFECTS WERE SEVERE MYELOSUPPRESSION, NAUSEA, VOMITING, MUCOSITIS, CARDIOTOXICITY, TINNITUS AND HEARING LOSS (MILD). |
| Dose amount | 30.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |