Experiment 428680

Details

PropertyValue
Pharmacology
Administration routeINTRAGASTRIC
OrganismEmpty organism
CitationHONG,JY: WANG,ZY: SMITH,TJ: ZHOU,S: SHI,S: PAN,J: YANG,CS:. (1992). INHIBITORY EFFECTS OF DIALLYL SULFIDE ON THE METABOLISM AND TUMORIGENICITY OF THE TOBACCO-SPECIFIC CARCINOGEN 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE (NNK) IN A/J MOUSE LUNG.. 13(5)
Amount utilized
Compound isolated
DiseaseVS.4-(METHYLNETROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE INDUCED CARCINOGENESIS IN LUNG. PRETREATMENT WITH DIALLYL SULFIDE DECREASED THE INCIDENCE OF LUNG TUMORS FROM 100% TO 37.9% AND TUMOR MULTIPLICITY FROM 7.2 TUMORS/MOUSE TO 0.6. IN LUNG AND LIVER MICROSOMES THE RATE OF METABOLISM OF THE CARCINOGEN WAS SIGNIFICANTLY DECREASED.
Dose amount200.0 MG
Number1
Qualitative resultACTIVE
AnimalMOUSE
Per unitKG
Dose expressionDOSE