Experiment 428960
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Radianthus macrodactylus (STICHODACTYLIDAE) |
| Citation | MAHNIR,VM: KOZLOVSKAYA,EP:. (1991). STRUCTURE TOXICITY RELATIONSHIPS OF NEUROTOXIN RTX-III FROM THE SEA ANEMONE RADIANTHUS MACRODACTYLUS: MODIFICATION OF AMINO GROUPS.. 29(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | GUANIDINATION OF THE 3 OR 4 LYSINE RESIDUES DECREASED LETHALITY 2-FOLD ACETYLATION OF THE N-TERMINAL AMINO GROUP CAUSED A 12-FOLD DECREASE IN LETHALITY. THE TOXIN CONTAINING ACETYLATED LYS-4 OR 1 OF 3 C-TERMINAL LYSINE RESIDUES HAD HALF THE LETHAL POTENTCY. DIACETYLATED DERIVASIVES WERE 30-35-FOLD LESS TOXIC |
| Dose amount | 40.0 MCG |
| Number | 2 |
| Qualitative result | . |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | LD50 |