Experiment 429018
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | GU,WZ: BANERJEE,S: RAUCH,J: BRANDWEIN,SR:. (1992). SUPPRESSION OF RENAL DISEASE AND ARTHRITIS, AND PROLONGATION OF SURVIVAL IN MRL-LPR MICE TREATED WITH AN EXTRACT OF TRIPTERYGIUM WILFORDII HOOK F.. 35(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | MRL-PLR/LPR MICE WERE USED. THIS MOUSE DEVELOPS LYMPHADENOPATHY, SPLENOMEGALY, AND FATAL GLOMERULONEPHRITIS, ACCOMPANIED BY ANTINUCLEAR ANTIBODIES AND SERUM. MICE WERE DOSED 3 TIMES WEEKLY FROM AGE 7 TO 16 WEEKS AND THAN 5 TIMES WEEKLY TO THE AGE OF 21 WEEKS. LYMPHOPROLIFERATION WAS NOT SUPPRESSED AS MEASURED THE WEIGHT OF LYMPH NODES AND SPLEENS. |
| Dose amount | 140.0 MG |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | MOUSE |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Extract | H2O EXT |