Experiment 431057
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN DRINKING WATER |
| Organism | Empty organism |
| Citation | TULSIANI,DRP: TOUSTER,O:. (1992). EVIDENCE THAT SWAINSONINE PRETREATMENT OF RATS LEADS TO THE FORMATION OF AUTOPHAGIC VACUOLES AND ENDOSOMES WITH DECREASED CAPACITY TO MATURE TO, FUSE WITH, ACTIVE LYSOSOMES.. 296(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN TREATED ANIMALS MOST OF ACTIVITY OF ALPHA-D-MANNOSIDASE, BETA-D-GALACTOSIDASE, N-ACETYL-BETA-D-GLUCOSAMINIDASE AND ALPHA-L-FUCOSIDASE ARE FOUND IN A LYSOSOMAL FRACTION OF HIGHER DENSITY THAN IN CONTROLS. TREATMENT WITH COMPOUND ALSO PREVENTED CHLOROQUINE AND VINBLASTINE-INDUCED SHIFT IN ENZYME ACTIVITY TO LIGHTER DENSITY LYSOSOMAL FRACTION. COMPOUND ALSO INHIBITS DEGRADATION OF ENDOCYTOSED ASIALOFETUIN THROUGH ALTERATION OF LYSOSOMAL MEMBRANE STABILITY. |
| Dose amount | 5.0 MCG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | ML |
| Dose expression | CONC USED |