Experiment 438809

Worktypes

STRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODEPHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

FLAVONE,7-8-DIHYDROXY:

Alerts

INHIBITON OF THE LYSOSOMAL MEMBRANE DETERIORATION INDUCED BY INCUBATION WITH THE OXYGEN FREE RADICAL GENERATING SYSTEM XANTHINE-XANTHINE OXIDASE WAS ASSAYED. MEASUREMENT OF THE FREE ACTIVITY OF N-ACETYLGLUCOSAMINEIDASE INCREASE WAS USED AS A MEASUREMENT OF MEMBRANE DETERIORATION.

Details

PropertyValue
Pharmacology
LYSOSOMAL MEMBRANE STABILIZATION EFFECT
OrganismEmpty organism
CitationDECHARNEUX,T: DUBOIS,F: BEAULOYE,C: WATTIAUX-DE CONINCK,S: WATTIAUX,R:. (1992). EFFECT OF VARIOUS FLAVONOIDS ON LYSOSOMES SUBJECTED TO AN OXIDATIVE OR AN OSMOTIC STRESS.. 44(7)
Amount utilized
Compound isolated
Disease80-100% INHIBITION OF N-ACETYLGLUCOSAMINIDASE FREE ACTIVITY INCREASE WAS OBSERVED.
Dose amount0.1 MILLIMOLS
Number1
Qualitative resultACTIVE
Dose expressionCONC USED