Experiment 441755
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | BISSETT,D: SETANOIANS,A: CASSIDY,J: GRAHAM,MA: CHADWICK,GA: WILSON,P: AUZANNET,V: LE BAIL,N: KAYE,SB: KERR,DJ:. (1993). PHASE I AND PHARMACOKINETIC STUDY OF TAXOTERE (RP 56976) ADMINISTERED AS A 24-HOUR INFUSION.. 53(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | 30 PATIENTS WITH SOLID TUMORS REFRACTORY TO CONVENTIONAL THERAPY WERE TREATED IN THIS PHASE 1 STUDY. 70 COURSES OF TAXOTERE WITH DOSES RANGING FROM 10 TO 90 MG/SQ. M. WERE GIVEN. GRADE 4 NEUTROPENIA AND GRADE 3 MUCOSITIS WERE DOSE LIMITING. OTHER TOXICITIES INCLUDED ALOPECIA, PHLEBITIS, DIARRHEA, EMESIS & SENSORY PERIPHERAL NEUROPATHY. NO PARTIAL OR COMPLETE RESPONSES WERE DOCUMENTED. THE END-OF-FUSION PLASMA CONCENTRATIONS EXCEEDED DRUG CONCENTRATION WHICH WERE CYTOTOXIC IN VITRO. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |