Experiment 442357

Details

PropertyValue
Pharmacology
Administration routeIV INFUSION
OrganismEmpty organism
CitationMURPHY,WK: FOSSELLA,FV: WINN,RJ: SHIN,DM: HYNES,HE: GROSS,HM: DAVILLA,E: LEIMERT,J: DHINGRA,H: RABER,MR: KRAFOFF,IR: HONG,WK:. (1993). PHASE II STUDY OF TAXOL IN PATIENTS WITH UNTREATED ADVANCED NON-SMALL-CELL LUNG CANCER.. 85(5)
Amount utilized
Compound isolated
Disease25 PATIENTS WITH UNTREATED ADVANCED NON-SMALL CELL LUNG CANCER WERE TREATED IN THIS PHASE 2 STUDY. PATIENTS WERE GIVEN TAXOL IN DOSES OF 200 MG/SQ. M OVER 24 HOURS AND REPEATED EVERY 3 WEEKS FOR UP TO A MAXIMUM OF 9 COURSES AND A MINUMUM OF 2. THE OVERALL RESPONSE RATE WAS 24% WITH 1 COMPLETE RESPONSE AND 5 PARTIAL REPONSES. GRANULOCYTOPENIA WAS THE DOSE LIMITING TOXICITY. OTHER TOXICITES INCLUDED NEUTROPENIC FEVER, NEUTROPENIC SEPSIS WITH HYPOTENSION, ANEMIA, THROMBOCYTOPENIA, FATIGUE, DIARRHEA, ALOPECIA, NAUSEA, EDEMA, DYSPNEA, HEADACHE AND ANOREXIA.
Dose amount200.0 MG
Number1
Qualitative result.
AnimalHUMAN ADULT
Per unitSQ M
Dose expressionDOSE