Experiment 442387
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | ISAKOV,N: GALRON,D: MUSTELIN,T: PETTIT,GR: ALTMAN,A:. (1993). INHIBITION OF PHORBOL ESTER-INDUCED T CELL PROLIERATION BY BRYOSTATIN IS ASSOCIATED WITH RAPID DEGRADATION OF PROTEIN KINASE C.. 150(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | EXPOSURE TO CMPD FOR 1 HR INDUCED COMPLETE CYTOSOL-TO-MEMBRANE TRANSLOCATION OF THREE ISOZYMES OF PKC AND PHOSPHORYLATION OF CELLULAR PROTEINS IN PATTERN SIMILAR TO THAT INDUCED BY PHORBOL MYRISTATE ACETATE (PMA). EXPOSURES OF 24 HRS RESULT IN DECREASED PKC ACTIVITY. THROUGH SUCH EXPOSURES TO PMA DOES NOT HAVE THIS EFFECT, CONCURRENT EXPOSURES TO PMA AND CMPD DO. |
| Dose amount | 20.0 NANOMOLS |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | CONC USED |