Experiment 444821
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Salvia officinalis (LAMIACEAE) |
| Citation | RUTHERFORD,DM: NIELSEN,MPC: HANSEN,SK: WITT,MR: BERGENDORFF,O: STERNER,O:. (1992). ISOLATION AND IDENTIFICATION FROM SALVIA OFFICINALIS OF TWO DITERPENES WHICH INHIBIT-T-BUTYLBICYCLOPHOSPHORAL[35S]THIONATE BINDING TO CHLORIDE CHANNEL OF RAT CEREBROCORTICAL MEMBRANES IN VITRO.. 135(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | CMPD INHIBITED BINDING OF LABELLED-T-BUTYLBICYCLOPHOSPHOROTHIONATE TO GABA RECEPTOR. CMPD DID NOT AFFECT BINDING OF MUSCIMOL TO GABA SITE OR DIAZEPHAM TO BENZODIAZEPINE SITE. |
| Dose amount | 57.0 MICROMOLS |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | IC50 |