Experiment 445170

Worktypes

PHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

CAMPTOTHECIN

Details

PropertyValue
Pharmacology
DNA SCISSION EFFECT
OrganismEmpty organism
CitationONISHI,Y: AZUMA,Y: SATO,Y: MIZUNO,Y: TADAKUMA,T: KIZAKI,H:. (1993). TOPOISOMERASE INHIBITORS INDUCED APOPTOSIS IN THYMOCYTES.. 1175(2)
Amount utilized
Compound isolated
Disease24 HR INCUBATION WITH COMPOUND RESULTED IN 63.6% DNA FRAGMENTATION. EFFECT INHIBITED BY NA AZIDE, ZINC, ACTINOMYCIN D, CYCLOHEXIMIDE AND H7 (INHIBITOR OF PROTEIN KINASE); PHORBOL 12,13-DIBUTYRATE, APHIDICOLIN (DNA POLY. INHIBITOR) A QUINAZOLINE(POLY-ADP-RIBOSYLATION INHIBITOR) HAD NO EFFECT ON FRAGMENTATION.
Dose amount10.0 MICROMOLS
Number1
Qualitative resultACTIVE
AnimalMOUSE
Dose expressionCONC USED