Experiment 445172

Worktypes

PHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

ETOPOSIDE*

Details

PropertyValue
Pharmacology
DNA SCISSION EFFECT
OrganismEmpty organism
CitationONISHI,Y: AZUMA,Y: SATO,Y: MIZUNO,Y: TADAKUMA,T: KIZAKI,H:. (1993). TOPOISOMERASE INHIBITORS INDUCED APOPTOSIS IN THYMOCYTES.. 1175(2)
Amount utilized
Compound isolated
Disease24 HR INCUBATION WITH COMPOUND RESULTED IN 77.2% DNA FRAGMENTATION. EFFECT ENHANCED BY PHORBOL 12, 13-DIBUTYRATE AND INHIBITED BY NA AZIDE, ZN, ACTINOMYCIN D, CYCLOHEXIMIDE AND H7(PROTEIN KINASE INHIBITOR). APHIDICOLIN (DNA POLY.INHIBITOR) ANDQUINAZOLINE (POLY-ADP-RIBOSYLATION INHIBITOR) HAD NO EFFECT ON FRAGMENTATION.
Dose amount10.0 MICROMOLS
Number1
Qualitative resultACTIVE
AnimalMOUSE
Dose expressionCONC USED