Experiment 445685
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | KANTARJIAN,HM: BERAN,M: ELLIS,A: ZWELLING,L: O'BRIEN,S: CAZENAVE,L: KOLLER,C: RIOS,MB: PLUNKETT,W: KEATING,MJ: ESTEY,EH:. (1993). PHASE I STUDY OF TOPOTECAN, A NEW TOPOISOMERASE I INHIBITOR, IN PATIENTS WITH REFRACTORY OR RELAPSED ACUTE LEUKEMIA.. 81(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | 27 PATIENTS WITH REFRACTORY OR RELAPSED ACUTE LEUKEMIA WERE USED IN THIS PHASE 1 STUDY. THE PATIENTS WERE DOSED EVERY 3-4 WEEKS BY CONTINOUS 5 DAY INFUSION. THE DOSE LIMITING TOXICITY WAS SEVERE MUCOSISTIS. NAUSEA, VOMITING, DIARRHEA AND PROLONGED MYELOSUPPRESISON WERE UNCOMMON. 11% OF THE PATIENTS ACHIEVED A COMPLETE RESPONSE, 7% SHOWED A PARTIAL RESPONSE AND 4% SHOWED HEMATOLOGIC IMPROVEMENT. THE OVERALL COMPLETE AND PARTIAL RESPONSE WAS 19% AND 24% ACUTE MYELOGENOUS OR UNDIFFERENTIATED LEUKEMIA. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |