Experiment 445738
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | EXTRA,JM: ROUSSEAU,F: BRUNO,R: CLAVEL,M: LE BAIL,N: MARTY,M:. (1993). PHASE I AND PHARMACOKINETIC STUDY OF TAXOTERE (RP 56076; NSC 628503) GIVEN AS A SHORT INTRAVENOUS INFUSION.. 53(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | 65 PATIENTS WITH HISTOLOGICALLY PROVEN MALIGNANCY NOT AMENABLE TO STANDARD THERAPY WERE USED IN THIS PHASE 1 STUDY. THE PATIENTS WERE DOSED EVERY 2-3 WEEKS IN DOSES RANGING FROM 5-115 MG.SQ.M. DOSE DEPENDENT, REVERSIBLE NEUTROPENIA WAS THE DOSE LIMITING TOXICITY. SKIN REACTIONS AND ALOPECIA OCCURED IN PATIENTS DOSED ABOVE 70 MG/SQ.M. 4 PARTIAL RESPONSES WERE ACHIEVED IN PATIENTS WITH OVARIAN CARCINOMA, BREAST CARCINOMA, SMALL CELL LUNG CANCER AND CARCINOMA OF UNKNOWN PRIMARY. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |