Experiment 445740
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | BLANEY,SM: BALIS,FM: COLE,DE: CRAIG,C: REID,JM: AMES,MM: KRAILO,M: REAMAN,G: HAMMOND,D: POPLACK,DG:. (1993). PEDIATRIC PHASE I TRIAL AND PHARMACOKINETIC STUDY OF TOPOTECAN ADMINISTERED AS A 24-HOUR CONTINUOUS INFUSION.. 53(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | 29 PEDIATRIC PATIENTS WITH REFRACTORY MALIGNANCIES WERE USED IN THIS PHASE 1 STUDY. PATIENTS WERE GIVEN DOSES RANGING FROM 2.0 TO 7.5 MG/SQ.M. EVERY 21 DAYS. THE PATIENTS EXPERIENCED DOSE LIMITING THROMBOCYTOPENIA AND NEUTROPENIA. NO OTHER DOSE LIMITING TOXICITIES WERE OBSERVED. NAUSEA AND VOMITING WERE MILD AND OCCURED IN <20% AND 10% OF PATIENTS RESPECTIVELY. NO OBJECTIVE RESPONSES WERE OBSERVED. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |