Experiment 445741
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | BLANEY,SM: BALIS,FM: COLE,DE: CRAIG,C: REID,JM: AMES,MM: KRAILO,M: REAMAN,G: HAMMOND,D: POPLACK,DG:. (1993). PEDIATRIC PHASE I TRIAL AND PHARMACOKINETIC STUDY OF TOPOTECAN ADMINISTERED AS A 24-HOUR CONTINUOUS INFUSION.. 53(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | PHARMACOKINTEIC STUDIES REVEALED A LINEAR RELATIONSHIP BETWEEN STEADY-STATE TOPOTECAN CONCENTRATION AND DOSE. THE ELIMINATION TIME AT THE MAXIUM TOLERATED DOSE WAS BIEXPONENTIAL WITH AN ALPHA HALF-LIFE OF 14.4 MINUTES AND A BETA HAL-LIFE OF 2.9 HOURS. |
| Dose amount | VAR |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |