Experiment 449448
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ROUTE NOT GIVEN |
| Organism | Empty organism |
| Citation | RUSSELL,JC: KOESLAG,DG: DOLPHIN,PJ: AMY,RM:. (1993). BENEFICIAL EFFECTS OF ACARBOSE IN THE ATHEROSCLEROSIS-PRONE JCR:LA-CORPULENT RAT.. 42(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | JCR:LA CORPULENT RATS WERE USED IN THIS STUDY. THESE RATS EXHIBIT MARKED OBESITY AND METABOLIC ADERANGEMENTS CHARACTERIZED BY HYPERLIPIDEMIA DUE TO HYPERSECRETION OF VLDL CHOLESTEROL AND SEVERE INSULIN RESISTANCE. THEY ALSO SPONTANEOUSLY DEVELOP ATHEROSCLEROSIS AND ISCHEMIC MYOCARDIAL LESIONS. ACARBOSE DECREASED THE OCCURANCE OF OLD SCARRED MYOCARDIOAL LESIONS. |
| Number | 7 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |