Experiment 449814

Details

PropertyValue
Pharmacology
Administration routeIV INFUSION
OrganismEmpty organism
CitationBURRIS,H: IRVIN,R: KUHN,J: KOLTER,S: SMITH,L: SHAFFER,D: FIELDS,S: WEISS,G: ECKARDT,J: RODRIGUEZ,G: RINOLDI,D: WALL,J: COOK,G: SMITH,S: VREELAND,F: BAYSSAS,M: LE BAIL,N: VON HOFF,D:. (1993). PHASE I CLINICAL TRIAL OF TAXOTERE ADMINISTERED AS EITHER A 2-HOUR OR 6-HOUR INTRAVENOUS INFUSION.. 11(5)
Amount utilized
Compound isolated
Disease58 PATIENTS WITH A VARIETY OF SOLID TUMORS REFRACTORY TO CONVENTIONAL THERAPY WERE USED IN THIS PHASE 1 STUDY. PATIENTS WERE GIVEN INFUSIONS EVERY 21 DAYS. THE DOSE LIMITING TOXICITY WAS NEUTROPENIA. OTHER TOXICITIES INCLUDED MUCOSITIS, RASH, ALOPECIA AND HYPERSENSITIVITY REACTIONS. 5 PATIENTS SHOWED PARTIAL RESPONSES AND 10 PATIENTS HAD MINOR RESPONSES.
Dose amountVAR
Number1
Qualitative result.
AnimalHUMAN ADULT
Dose expressionDOSE