Experiment 451260

Compounds isolated

Details

PropertyValue
Pharmacology
OrganismEmpty organism
CitationKOWALSKA-LOTH,B: STARON,K: BURACZEWSKA,I: SZUMIEL,I: KAPISZEWSKA,M: LANGE,CS:. (1993). REDUCED SENSITIVITY TO CAMPTOTHECIN OF TOPOISOMERASE I FROM A L5178Y MOUSE LYMPHOMA SUBLINE SENSITIVE TO X-RADIATION.. 1172(1/2)
Amount utilized
Compound isolated
DiseaseRADIATION-SENSITIVE SUBLINE SHOWED GREATER RESISTANCE TO CMPD, BUT NOT TO OTHER TOPO I INHIBITORS. RESISTANCE SEEN IN DECREASED DNA-PROTEIN CROSS-LINKING AND IN NUCLEOID HALOASSAY.
Dose amount1.0 MICROMOLS
Number1
Qualitative resultACTIVE
Dose expressionCONC USED