Experiment 453150
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | ROWINSKY,EK: NOE,DA: ETTINGER,DS: CHRISTIAN,MC: LUBEJKO,BG: FISHMAN,EK: SARTORIUS,SE: BOYD,MR: DONEHOWER,RC:. (1993). PHASE I AND PHARMACOLOGICAL STUDY OF THE PULMONARY CYTOTOXIN 4-IPOMEANOL ON A SINGLE DOSE SCHEDULE IN LUNG CANCER PATIENTS: HEPATOTOXICITY IS DOSE LIMITING IN HUMANS.. 53(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | 55 PATIENTS WITH ADVANCED NON-SMALL AND SMALL CELL LUNG CANCERS WERE USED IN THIS PHASE I STUDY. PATIENTS WERE GIVEN DOSES RANGING FROM 6.5 TO 16.2 MG/SQ.M. THE DOSE LIMITING TOXICITY WAS HEPATOCELLULAR TOXICITY. NEPHROTOXICITY AND REVERSIBLE PULMONARY TOXICITY WAS ALSO NOTED. NO OBJECTIVE ANTITUMOR RESPONSES WERE OBSERVED; HOWEVER, STABLE DISEASE PERSISTED FOR AT LEAST 8 COURSES IN 27% OF PATIENTS. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |